Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.70 |
| ▸ | RAB9A | P51151 | 5/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | CA12 | O43570 | 2/20 | 0.67 |
| ▸ | CA1 | P00915 | 2/20 | 0.67 |
| ▸ | CA2 | P00918 | 2/20 | 0.67 |
| ▸ | CA9 | Q16790 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.59 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | KLK7 | P49862 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943804 | 0.85 | P2RY1 (0.58) | NPC1RAB9ASMN1; SMN2CA12CA1 | |
| SCHEMBL6934964 | 0.84 | RAB9A (0.62) | NPC1RAB9ASMN1; SMN2CA12CA1 | |
| SCHEMBL8105102 | 0.83 | MAPT (0.69) | NPC1RAB9ASMN1; SMN2CA12CA1 | |
| SCHEMBL27193044 | 0.78 | RAB9A (0.77) | NPC1RAB9ASMN1; SMN2CA12CA1 | |
| SCHEMBL16946643 | 0.77 | MAPT (0.76) | NPC1RAB9ASMN1; SMN2CA12CA1 | |
| SCHEMBL17609477 | 0.77 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2CA12CA1 | |
| SCHEMBL19888870 | 0.77 | RAF1 (0.68) | NPC1RAB9ASMN1; SMN2CA9KDR | |
| SCHEMBL4684136 | 0.76 | PARP10 (0.44) | NPC1RAB9ASMN1; SMN2MAPTGAA | |
| SCHEMBL672116 | 0.76 | CA2 (1.00) | NPC1RAB9ASMN1; SMN2CA12CA1 | |
| SCHEMBL15133005 | 0.75 | RAB9A (0.68) | NPC1RAB9ASMN1; SMN2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042278-A1 | 1,3-DISUBSTITUTED UREAS AS ACAT INHIBITORS, AND METHOD OF PREPARING THEREOF | Slovakofarma, A.S. (SK) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032437-A1 | 1,3-DISUBSTITUTED UREAS AS ACAT INHIBITORS, AND METHOD OF PREPARING THEREOF | SLOVAKOFARMA, A.S. (SK) | 1999-07-01 | — | — | WO | disclosed |