Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8095658 | 0.85 | NPC1 (0.70) | RAB9ANPC1SMN1; SMN2HTTCA12 | |
| SCHEMBL6940403 | 0.83 | MAPT (0.61) | P2RY1RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL3159880 | 0.79 | P2RY1 (0.72) | P2RY1RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL6934961 | 0.77 | RAB9A (0.54) | P2RY1RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL8103125 | 0.77 | P2RY1 (0.55) | P2RY1RAB9ASMN1; SMN2HTTCA12 | |
| SCHEMBL7070334 | 0.76 | GAA (0.56) | RAB9ANPC1SMN1; SMN2PKMCA12 | |
| SCHEMBL6943396 | 0.76 | ALDH1A1 (0.61) | RAB9ANPC1CA12CA1CA2 | |
| SCHEMBL27193044 | 0.76 | RAB9A (0.77) | RAB9ANPC1SMN1; SMN2HTTPKM | |
| SCHEMBL4865713 | 0.76 | ADRA2C (0.54) | RAB9ASMN1; SMN2PKMCA12CA1 | |
| SCHEMBL6943988 | 0.74 | MAPT (0.59) | RAB9ANPC1SMN1; SMN2HTTCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042278-B1 | 1,3-DISUBSTITUTED UREAS AS ACAT INHIBITORS, AND METHOD OF PREPARING THEREOF | SLOVAKOFARMA AS (SK) | 2003-03-05 | — | — | EP | disclosed |
| US-6444691-B1 | ANTICHOLESTEROL AGENTS | SOLVAKOFARMA, A.S. (SK) | 2002-09-03 | — | — | US | disclosed |
| EP-1042278-A1 | 1,3-DISUBSTITUTED UREAS AS ACAT INHIBITORS, AND METHOD OF PREPARING THEREOF | Slovakofarma, A.S. (SK) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032437-A1 | 1,3-DISUBSTITUTED UREAS AS ACAT INHIBITORS, AND METHOD OF PREPARING THEREOF | SLOVAKOFARMA, A.S. (SK) | 1999-07-01 | — | — | WO | disclosed |