⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097942 | 0.81 | FAAH (0.32) | — | |
| SCHEMBL8107056 | 0.79 | — | — | |
| SCHEMBL8099673 | 0.77 | GABRA1 (0.34) | — | |
| SCHEMBL8105465 | 0.77 | PARP1 (0.35) | — | |
| SCHEMBL8089757 | 0.77 | — | — | |
| SCHEMBL8090361 | 0.72 | CYP3A4 (0.32) | — | |
| SCHEMBL9647671 | 0.71 | — | — | |
| SCHEMBL9647187 | 0.70 | ALDH1A1 (0.36) | — | |
| SCHEMBL8099224 | 0.69 | KDM4E (0.35) | — | |
| SCHEMBL8096885 | 0.69 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626372-B1 | 2-hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]benzenecarboximid-amides for the treatment of glaucoma | UCB SA (BE) | 2000-12-20 | — | — | EP | claimed |
| EP-0626372-A1 | 2-hydroxy-3- 1-(1H-imidazol-4-yl)alkyl benzenecarboximid-amides for the treatment of glaucoma | U C B, S.A. (BE) | 1994-11-30 | — | — | EP | claimed |
| EP-0341231-B1 | SUBSTITUTED 1-(1H-IMIDAZOL-4-YL)ALKYL BENZAMIDES | U C B, S.A. (BE) | 1992-11-19 | — | — | EP | claimed |
| EP-0341231-A1 | Substituted 1-(1H-imidazol-4-yl)alkyl benzamides | U C B, S.A. (BE) | 1989-11-08 | — | — | EP | claimed |
| JP-7070082-A | — | — | None | — | — | JP | disclosed |
| EP-0626372-B1 | 2-hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]benzenecarboximid-amides for the treatment of glaucoma | UCB SA (BE) | 2000-12-20 | — | — | EP | disclosed |
| JP-H0770082-A | 2-HYDROXY-3-(1-(1H-IMIDAZOL-4-YL) ALKYL)BENZENECARBOXIMIDAMIDE | UCB SA | 1995-03-14 | — | — | JP | disclosed |
| US-5385927-A | Hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]-benzenecarboximidamides and their use in treating glaucoma | U C B, S.A. (BE) | 1995-01-31 | — | — | US | disclosed |
| EP-0626372-A1 | 2-hydroxy-3- 1-(1H-imidazol-4-yl)alkyl benzenecarboximid-amides for the treatment of glaucoma | U C B, S.A. (BE) | 1994-11-30 | — | — | EP | disclosed |
| EP-0341231-B1 | SUBSTITUTED 1-(1H-IMIDAZOL-4-YL)ALKYL BENZAMIDES | U C B, S.A. (BE) | 1992-11-19 | — | — | EP | disclosed |
| US-4923865-A | Substituted 1-(1H-imidazol-4-yl)alkyl-benzamides as anti-ischemics and as alpha-2-adrenergic receptor agonists | U C B SOCIETE ANONYME (BE) | 1990-05-08 | — | — | US | disclosed |
| US-4923865-A | Substituted 1-(1H-imidazol-4-yl)alkyl-benzamides as anti-ischemics and as alpha-2-adrenergic receptor agonists | U C B SOCIETE ANONYME (BE) | 1990-05-08 | — | — | US | disclosed |
| EP-0341231-A1 | Substituted 1-(1H-imidazol-4-yl)alkyl benzamides | U C B, S.A. (BE) | 1989-11-08 | — | — | EP | disclosed |
| EP-0341231-A1 | Substituted 1-(1H-imidazol-4-yl)alkyl benzamides | U C B, S.A. (BE) | 1989-11-08 | — | — | EP | disclosed |