Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092975 | 0.86 | SIGMAR1 (0.62) | EPHX2SIGMAR1L3MBTL1MEN1KMT2A | |
| SCHEMBL20545401 | 0.84 | ALDH1A1 (0.50) | EPHX2SIGMAR1 | |
| SCHEMBL15901399 | 0.79 | EPHX2 (0.42) | EPHX2 | |
| SCHEMBL20908974 | 0.79 | SMN1; SMN2 (0.54) | EPHX2 | |
| SCHEMBL15131171 | 0.79 | SIGMAR1 (0.65) | EPHX2SIGMAR1L3MBTL1MEN1KMT2A | |
| SCHEMBL24504966 | 0.79 | SMN1; SMN2 (0.54) | EPHX2 | |
| SCHEMBL13171301 | 0.79 | HRH1 (0.46) | EPHX2 | |
| SCHEMBL8096671 | 0.79 | SIGMAR1 (0.61) | EPHX2SIGMAR1KDM4A | |
| SCHEMBL13911223 | 0.78 | SIGMAR1 (0.48) | EPHX2SIGMAR1MEN1KMT2A | |
| SCHEMBL10936922 | 0.78 | SIGMAR1 (0.58) | SIGMAR1L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |