Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.35 |
| ▸ | FEN1 | P39748 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SGK1 | O00141 | 3/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084961 | 0.91 | NAMPT (0.41) | NAMPTPIK3CAPIK3CDMAPT | |
| SCHEMBL8095173 | 0.90 | NAMPT (0.39) | NAMPTPIK3CAPIK3R1PIK3CDMAPT | |
| SCHEMBL8091502 | 0.89 | NAMPT (0.39) | NAMPTPIK3CAPIK3R1PIK3CDMAPT | |
| SCHEMBL8100826 | 0.88 | NAMPT (0.40) | NAMPTPIK3CAPIK3CDMAPT | |
| SCHEMBL8083416 | 0.87 | PIK3R1 (0.39) | NAMPTPIK3CAPIK3R1ALOX5APFEN1 | |
| SCHEMBL3925717 | 0.81 | PIK3CA (0.55) | PIK3CAPIK3R1PIK3CD | |
| SCHEMBL8104327 | 0.81 | NAMPT (0.39) | NAMPTPIK3CAPIK3CD | |
| SCHEMBL8090580 | 0.81 | NAMPT (0.39) | NAMPTPIK3CAPIK3CDSGK1 | |
| SCHEMBL8100133 | 0.81 | NAMPT (0.41) | NAMPTPIK3CAPIK3CDMAPT | |
| SCHEMBL8090837 | 0.80 | MTOR (0.38) | NAMPTPIK3CAPIK3CDMAPTROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |