Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | SGK1 | O00141 | 11/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104712 | 0.90 | IDO1 (0.40) | PIK3CASGK1IDO1TDO2KIF11 | |
| SCHEMBL8082685 | 0.90 | IDO1 (0.40) | PIK3CASGK1IDO1TDO2ALDH1A1 | |
| SCHEMBL8090834 | 0.89 | KIF11 (0.35) | IDO1TDO2KIF11MEN1ALDH1A1 | |
| SCHEMBL8090786 | 0.89 | SGK1 (0.37) | SGK1F10MEN1ALDH1A1MAPT | |
| SCHEMBL8091143 | 0.89 | KIF11 (0.36) | PIK3CASGK1F10KIF11MEN1 | |
| SCHEMBL8096684 | 0.87 | NAMPT (0.39) | PIK3R1PIK3CASGK1ALOX5APFEN1 | |
| SCHEMBL8095173 | 0.87 | NAMPT (0.39) | PIK3R1PIK3CASGK1MAPTNAMPT | |
| SCHEMBL8091293 | 0.86 | MAPT (0.42) | PIK3R1PIK3CAKIF11MEN1ALDH1A1 | |
| SCHEMBL8091502 | 0.86 | NAMPT (0.39) | PIK3R1PIK3CASGK1MAPTNAMPT | |
| SCHEMBL8084982 | 0.85 | KIF11 (0.38) | IDO1TDO2KIF11MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |