Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | FNTA | P49354 | 1/20 | 0.48 |
| ▸ | FNTB | P49356 | 1/20 | 0.48 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RHOA | P61586 | 12/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088938 | 0.86 | KDM4E (0.46) | KCNH2FNTAFNTBPGGT1BALDH1A1 | |
| SCHEMBL8097852 | 0.86 | KDM4E (0.46) | KCNH2FNTAFNTBPGGT1BALDH1A1 | |
| SCHEMBL8088954 | 0.85 | ATM (0.46) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8103721 | 0.83 | ITGB3 (0.39) | KMT2A | |
| SCHEMBL8088811 | 0.83 | GPR119 (0.44) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8097458 | 0.83 | ALOX12 (0.36) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8098292 | 0.83 | ATM (0.38) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8104346 | 0.83 | HPGD (0.43) | ALDH1A1RHOAKMT2A | |
| SCHEMBL8095919 | 0.82 | ALOX12 (0.40) | KMT2A | |
| SCHEMBL8088397 | 0.82 | GAA (0.39) | FNTAFNTBALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127366-A | ANTICARCINOGENIC OR ANTITUMOR AGENTS | MERCK & CO., INC. (US) | 2000-10-03 | — | — | US | disclosed |
| EP-0862435-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-02-03 | — | — | EP | disclosed |
| US-5817678-A | IMIDAZOLE-CONTAINING PIPERIDINE DERIVATIVES, PEPTIDEMIMETIC | MERCK & CO., INC. (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0862435-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997018813-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-05-29 | — | — | WO | disclosed |