Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 14/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099061 | 0.91 | OPRL1 (0.50) | OPRL1OPRM1OPRD1OPRK1POLB | |
| SCHEMBL11711744 | 0.82 | OPRL1 (0.46) | OPRL1OPRM1OPRD1OPRK1POLB | |
| SCHEMBL7093690 | 0.78 | OPRL1 (0.56) | OPRL1OPRM1OPRD1OPRK1POLB | |
| SCHEMBL9373502 | 0.78 | OPRM1 (0.48) | OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL18916776 | 0.77 | OPRM1 (0.46) | OPRL1OPRM1OPRD1OPRK1POLB | |
| SCHEMBL10424519 | 0.77 | HTR1A (0.59) | — | |
| SCHEMBL11621822 | 0.77 | PKM (0.40) | OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL8213555 | 0.75 | OPRL1 (0.67) | OPRL1OPRM1OPRD1OPRK1POLB | |
| SCHEMBL27345562 | 0.74 | OPRL1 (0.56) | OPRL1OPRM1OPRD1OPRK1POLB | |
| SCHEMBL17543847 | 0.74 | KMT2A (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | claimed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | claimed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |