Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097764 | 0.85 | HDAC4 (0.46) | SMN1; SMN2NPSR1SLC9A1KDM4EHDAC4 | |
| SCHEMBL6249889 | 0.84 | KDM1A (0.42) | SLC18A3KDM1A | |
| SCHEMBL11458171 | 0.83 | HDAC4 (0.44) | SMN1; SMN2NPSR1SLC9A1KDM4EHDAC4 | |
| SCHEMBL13834342 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2NPSR1MAPK1TDP1HDAC4 | |
| SCHEMBL24658450 | 0.82 | KDM1A (0.44) | KDM1ASLC6A3 | |
| SCHEMBL14714313 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2NPSR1SLC9A1KDM4EHDAC4 | |
| SCHEMBL14714314 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2NPSR1SLC9A1KDM4EHDAC4 | |
| SCHEMBL6249011 | 0.81 | GABRA1 (0.52) | KDM1AMAPTHPGDSLC6A3 | |
| SCHEMBL7274841 | 0.81 | FABP5 (0.57) | SMN1; SMN2NPSR1SLC18A3KDM4E | |
| SCHEMBL4193266 | 0.81 | FABP5 (0.61) | SMN1; SMN2NPSR1SLC18A3KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7648988-B2 | Substituted pteridines for the treatment of inflammatory diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH | 2010-01-19 | — | — | US | disclosed |
| US-20080153833-A1 | Substituted pteridines for the treatment of inflammatory diseases | DOLLINGER HORST | 2008-06-26 | — | — | US | disclosed |
| US-20060116370-A1 | Substituted pteridines for the treatment of inflammatory diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116370-A1 | Substituted pteridines for the treatment of inflammatory diseases | LTC4S, TLR5, LTB4R2 | SMN1; SMN2 2164/4885NPSR1 1216/4885SLC18A3 1503/4885 |
| US-20080153833-A1 | Substituted pteridines for the treatment of inflammatory diseases | LTC4S, TLR5, LTB4R2 | SMN1; SMN2 2164/4885NPSR1 1216/4885SLC18A3 1503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.