Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8096772 | 1.00 | ADRA2A (0.42) | ADRA2ACYP11B2CYP19A1CYP17A1LMNA | |
| Fumaric Acid SCHEMBL8092369 | 1.00 | ADRA2A (0.42) | ADRA2ACYP11B2CYP19A1CYP17A1LMNA | |
| Fumaric Acid SCHEMBL8092366 | 1.00 | ADRA2A (0.42) | ADRA2ACYP11B2CYP19A1CYP17A1LMNA | |
| Fumaric Acid SCHEMBL8097796 | 1.00 | ADRA2A (0.42) | ADRA2ACYP11B2CYP19A1CYP17A1LMNA | |
| Fumaric Acid SCHEMBL8096777 | 1.00 | ADRA2A (0.42) | ADRA2ACYP11B2CYP19A1CYP17A1LMNA | |
| SCHEMBL6960083 | 0.90 | ADRA2A (0.49) | ADRA2ACYP11B2CYP19A1CYP17A1 | |
| SCHEMBL8119984 | 0.90 | ADRA2A (0.49) | ADRA2ACYP11B2CYP19A1CYP17A1 | |
| SCHEMBL6955549 | 0.90 | ADRA2A (0.49) | ADRA2ACYP11B2CYP19A1CYP17A1 | |
| SCHEMBL8116582 | 0.90 | ADRA2A (0.49) | ADRA2ACYP11B2CYP19A1CYP17A1 | |
| SCHEMBL6953572 | 0.90 | ADRA2A (0.49) | ADRA2ACYP11B2CYP19A1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |