Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 7/20 | 1.00 |
| ▸ | MAOB | P27338 | 7/20 | 1.00 |
| ▸ | CDC7 | O00311 | 2/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.55 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.55 |
| ▸ | PRKACA | P17612 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | TGM2 | P21980 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | APAF1 | O14727 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2789935 | 0.85 | MAOA (1.00) | MAOAMAOBCES1TGM2MEN1 | |
| Tannin Pyrogallol SCHEMBL28906902 | 0.85 | MAOA (0.80) | MAOAMAOBMEN1LMNAMAPT | |
| Isatin SCHEMBL28299080 | 0.84 | MAOA (0.72) | MAOAMAOBMEN1APAF1NPC1 | |
| Biphenyl SCHEMBL1897547 | 0.82 | MAOA (0.83) | MAOAMAOBMEN1LMNAMAPT | |
| Isatin SCHEMBL28636865 | 0.81 | MAOA (0.80) | MAOAMAOBMEN1LMNAMAPT | |
| Tannin Pyrogallol SCHEMBL29283471 | 0.77 | MAOA (0.67) | MAOAMAOBMEN1LMNAMAPT | |
| SCHEMBL5873949 | 0.76 | SMN1; SMN2 (0.65) | MAOAMAOBCDC7ROCK2MAP4K4 | |
| SCHEMBL22314930 | 0.76 | CES1 (0.64) | MAOAMAOBCES1TGM2PDE3B | |
| Isatin SCHEMBL28365971 | 0.76 | MAOA (0.95) | MAOAMAOBCES1TGM2MEN1 | |
| SCHEMBL1276074 | 0.75 | TDP2 (0.61) | MAOAMAOBCDC7ROCK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828342-B2 | Isatin derivatives, pharmaceutical compositions thereof, and methods of use thereof | CITY OF HOPE (US) | 2017-11-28 | — | — | US | disclosed |
| EP-0747354-B1 | 3-Substituted oxindole derivatives as potassium channel modulators | BRISTOL MYERS SQUIBB CO (US) | 2000-08-16 | — | — | EP | disclosed |
| US-5602169-A | USEFUL IN REDUCING NEURONAL DAMAGE DURING ISCHEMIC STROKE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-02-11 | — | — | US | disclosed |
| EP-0747354-A1 | 3-Substituted oxindole derivatives as potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| US-5565483-A | ADMINISTERING AS THERAPY FOR ISCHEMIA, CONVULSIONS OR ASTHMA | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-15 | — | — | US | disclosed |