Isatin

Isatin

SCHEMBL28299080

O=C1Nc2ccccc2C1=O.c1ccc(-c2cccc(-c3ccccc3)c2)cc1

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 10/20 0.72
MAOB P27338 10/20 0.72
FLT3 P36888 2/20 0.50
ACVR1 Q04771 2/20 0.50
LRRK2 Q5S007 2/20 0.50
PDGFRA P16234 1/20 0.50
FER P16591 1/20 0.50
LTK P29376 1/20 0.50
CDK8 P49336 1/20 0.50
DYRK1B Q9Y463 1/20 0.50
PDE3B Q13370 1/20 0.50
PDE3A Q14432 1/20 0.50
CASP3 P42574 1/20 0.47
CASP2 P42575 1/20 0.47
CASP7 P55210 1/20 0.47
CASP6 P55212 1/20 0.47
CASP8 Q14790 1/20 0.47
CSNK1G1 Q9HCP0 1/20 0.46
MEN1 O00255 1/20 0.46
APAF1 O14727 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isatin SCHEMBL28636865 0.94 MAOA (0.80) MAOAMAOBFLT3ACVR1LRRK2
Biphenyl SCHEMBL1897547 0.93 MAOA (0.83) MAOAMAOBFLT3ACVR1LRRK2
Tannin Pyrogallol SCHEMBL28906902 0.91 MAOA (0.80) MAOAMAOBFLT3ACVR1LRRK2
Isatin SCHEMBL28365971 0.87 MAOA (0.95) MAOAMAOBFLT3ACVR1LRRK2
Isatin SCHEMBL34016 0.84 MAOA (1.00) MAOAMAOBACVR1LRRK2PDGFRA
Isatin SCHEMBL973760 0.84 MAOA (1.00) MAOAMAOBACVR1LRRK2PDGFRA
SCHEMBL2789935 0.84 MAOA (1.00) MAOAMAOBLRRK2PDE3BPDE3A
SCHEMBL8098010 0.84 MAOA (1.00) MAOAMAOBPDE3BPDE3AMEN1
Isatin SCHEMBL23256320 0.82 MAOA (0.95) MAOAMAOBACVR1LRRK2PDGFRA
Isatin SCHEMBL11646710 0.82 MAOA (0.95) MAOAMAOBACVR1LRRK2PDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109880138-B High-performance polyisatin arene with long side chain ammonium salt, anion exchange membrane thereof, preparation method and application 大连理工大学 2020-09-29 CN disclosed
CN-109880138-A High-performance polyisatin arene with long side chain ammonium salt, anion exchange membrane thereof, preparation method and application 大连理工大学 2019-06-14 CN disclosed