Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 5/20 | 0.48 |
| ▸ | SLC6A4 known ✓ | P31645 | 5/20 | 0.48 |
| ▸ | SLC6A3 known ✓ | Q01959 | 5/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3542111 | 0.80 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3HTR6NOS3 | |
| SCHEMBL3542115 | 0.80 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3HTR6NOS3 | |
| SCHEMBL3062717 | 0.79 | SLC6A4 (0.53) | SLC6A2SLC6A4SLC6A3HTR6NOS3 | |
| Hydrochloric Acid SCHEMBL6498978 | 0.78 | SLC6A4 (0.52) | SLC6A2SLC6A4SLC6A3HTR6NOS3 | |
| SCHEMBL8108438 | 0.76 | HTR6 (0.50) | SLC6A2SLC6A4SLC6A3HTR6NOS3 | |
| SCHEMBL6500944 | 0.74 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3HTR6NOS3 | |
| SCHEMBL1021448 | 0.72 | SLC6A2 (0.62) | SLC6A2SLC6A4SLC6A3HTR6NOS3 | |
| SCHEMBL1021447 | 0.72 | SLC6A2 (0.62) | SLC6A2SLC6A4SLC6A3HTR6NOS3 | |
| Cadaverine Tartrate SCHEMBL3542909 | 0.72 | SLC6A3 (0.48) | SLC6A2SLC6A4SLC6A3HTR6MEN1 | |
| SCHEMBL1020817 | 0.72 | SLC6A2 (0.69) | SLC6A2SLC6A4SLC6A3HTR6NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6107307-A | PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0969005-A1 | Azabicyclic inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1999065492-A1 | INHIBITION OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |