Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 3/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099563 | 0.90 | PIK3CA (0.38) | PIK3CDPIK3CAKITGAAMTOR | |
| SCHEMBL8107169 | 0.88 | MTOR (0.37) | PIK3CDPIK3CAKITMTORPIK3CG | |
| SCHEMBL8099251 | 0.84 | NAMPT (0.38) | PIK3CDPIK3CAGAAMTORPIK3CG | |
| SCHEMBL8084284 | 0.83 | NAMPT (0.39) | PIK3CDPIK3CAGAAMEN1MAPT | |
| SCHEMBL8099965 | 0.83 | NAMPT (0.39) | PIK3CDPIK3CARORCMAPTKDM4E | |
| SCHEMBL4203982 | 0.82 | MTOR (0.53) | PIK3CDPIK3CAMTORPIK3CGPIK3CB | |
| SCHEMBL8097253 | 0.82 | PIK3CD (0.36) | PIK3CDPIK3CAMTORMEN1MAPT | |
| SCHEMBL8093145 | 0.82 | MAPT (0.39) | PIK3CDPIK3CAMTORPIK3CGMEN1 | |
| SCHEMBL8089216 | 0.81 | NAMPT (0.41) | PIK3CDPIK3CAMTORKDR | |
| SCHEMBL8091502 | 0.81 | NAMPT (0.39) | PIK3CDPIK3CAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |