Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.38 |
| ▸ | MTOR | P42345 | 11/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098739 | 0.90 | PIK3CD (0.36) | PIK3CAMTORPIK3CDKDM4ERAB9A | |
| SCHEMBL8107169 | 0.88 | MTOR (0.37) | PIK3CAMTORPIK3CDPIK3CGKIT | |
| SCHEMBL8099632 | 0.85 | CA1 (0.42) | PIK3CAMTORPIK3CDRAB9AALDH1A1 | |
| SCHEMBL8091538 | 0.84 | PIK3CD (0.43) | PIK3CAMTORPIK3CDPIK3CGATR | |
| SCHEMBL8084009 | 0.84 | PIK3CD (0.42) | PIK3CAMTORPIK3CDPIK3CGATR | |
| SCHEMBL8104327 | 0.84 | NAMPT (0.39) | PIK3CAMTORPIK3CD | |
| SCHEMBL8091534 | 0.83 | NAMPT (0.40) | PIK3CAMTORPIK3CDSMN1; SMN2ALDH1A1 | |
| SCHEMBL8091717 | 0.83 | CA2 (0.40) | PIK3CAMTORPIK3CDKDM4E | |
| SCHEMBL8107163 | 0.82 | KDM4E (0.42) | PIK3CAMTORPIK3CDKDM4ERAB9A | |
| SCHEMBL8100136 | 0.82 | NAMPT (0.41) | PIK3CAMTORPIK3CDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |