Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | GALK1 | P51570 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091534 | 0.90 | NAMPT (0.40) | NAMPTPIK3CDPIK3CAMAPTALDH1A1 | |
| SCHEMBL8097253 | 0.85 | PIK3CD (0.36) | NAMPTPIK3CDPIK3CAMAPTMEN1 | |
| SCHEMBL8099965 | 0.84 | NAMPT (0.39) | NAMPTPIK3CDPIK3CAMAPTHTT | |
| SCHEMBL8098739 | 0.83 | PIK3CD (0.36) | PIK3CDPIK3CAMAPTGAAMEN1 | |
| SCHEMBL8099251 | 0.83 | NAMPT (0.38) | NAMPTPIK3CDPIK3CAMAPTGAA | |
| SCHEMBL4202020 | 0.83 | MTOR (0.53) | PIK3CDPIK3CA | |
| SCHEMBL8093145 | 0.83 | MAPT (0.39) | NAMPTPIK3CDPIK3CAMAPTMEN1 | |
| SCHEMBL8089194 | 0.83 | MTOR (0.38) | NAMPTPIK3CDMAPTALDH1A1TSHR | |
| SCHEMBL8089216 | 0.82 | NAMPT (0.41) | NAMPTPIK3CDPIK3CA | |
| SCHEMBL8091502 | 0.81 | NAMPT (0.39) | NAMPTPIK3CDPIK3CAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |