Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 9/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2047072 | 0.81 | DNM1 (0.48) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| Hydrochloric Acid SCHEMBL27487418 | 0.80 | DNM1 (0.43) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| Hydrochloric Acid SCHEMBL6558103 | 0.80 | SLC22A1 (0.52) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| Hydrochloric Acid SCHEMBL29218953 | 0.79 | SLC22A1 (0.58) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| Hydrochloric Acid SCHEMBL28360349 | 0.79 | SLC22A1 (0.58) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| SCHEMBL6558342 | 0.77 | SLC22A1 (0.55) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| SCHEMBL4543349 | 0.76 | SLC22A1 (0.61) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| SCHEMBL15912723 | 0.76 | SLC22A1 (0.61) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| SCHEMBL28755201 | 0.76 | SLC22A1 (0.61) | DNM1SLC22A1ALDH1A1TP53CYP3A4 | |
| SCHEMBL7169873 | 0.76 | DNM1 (0.50) | DNM1SLC22A1HTTHSP90AA1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842603-B1 | Agricultural chemical composition | KAO CORP (JP) | 2000-12-27 | — | — | EP | disclosed |
| EP-0638236-B1 | Agricultural chemical composition | KAO CORP (JP) | 1998-09-30 | — | — | EP | disclosed |
| EP-0842603-A1 | Agricultural chemical composition | KAO CORPORATION (JP) | 1998-05-20 | — | — | EP | disclosed |
| EP-0638236-A1 | Agricultural chemical composition | KAO CORPORATION (JP) | 1995-02-15 | — | — | EP | disclosed |