SCHEMBL8098993

SCHEMBL8098993

Cc1cc(N)ccc1C(C)c1ccc(C2(c3ccc(C(C)c4ccc(N)cc4C)cc3)CCC(C)CC2)cc1

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
RXRA P19793 1/20 0.33
HTT P42858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8098969 0.88 ALDH1A1 (0.33) ALDH1A1L3MBTL1RXRA
SCHEMBL8099570 0.85 ALDH1A1 (0.51) ALDH1A1L3MBTL1RXRAHTT
SCHEMBL8096055 0.85 ALDH1A1 (0.33) ALDH1A1L3MBTL1
SCHEMBL8094415 0.84 RXRA (0.31) ALDH1A1L3MBTL1RXRA
SCHEMBL8100366 0.83 ALDH1A1 (0.46) ALDH1A1L3MBTL1HTT
SCHEMBL8101932 0.83 CYP19A1 (0.31)
SCHEMBL8095629 0.82 CYP19A1 (0.32) ALDH1A1L3MBTL1
SCHEMBL8099950 0.82 CYP19A1 (0.32)
SCHEMBL8094099 0.81 CYP19A1 (0.33)
SCHEMBL8093879 0.81 CYP19A1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0708077-B1 Diamino compounds and methods for preparing them CHISSO CORP (JP) 2000-12-27 EP disclosed
US-5663440-A Diamino compounds and methods for preparing them CHISSO CORPORATION (JP) 1997-09-02 US disclosed
EP-0708077-A1 Diamino compounds and methods for preparing them CHISSO CORPORATION (JP) 1996-04-24 EP disclosed