Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104048 | 0.90 | PTGS2 (0.44) | KMT2APTGS1PTGS2EGFRP4HTM | |
| SCHEMBL8875058 | 0.88 | MEN1 (0.45) | MEN1KMT2ASMPD1PTGS1PTGS2 | |
| SCHEMBL8104049 | 0.87 | LMNA (0.39) | MEN1KMT2AEPHX2PPARG | |
| SCHEMBL8766943 | 0.85 | PTGS2 (0.48) | PTGS1PTGS2EGFRP4HTMMCL1 | |
| SCHEMBL8098997 | 0.85 | PPARG (0.45) | MEN1KMT2ASMPD1PPARG | |
| SCHEMBL8810655 | 0.82 | MEN1 (0.44) | MEN1KMT2A | |
| SCHEMBL8809005 | 0.82 | MEN1 (0.44) | MEN1KMT2A | |
| SCHEMBL8807170 | 0.82 | MEN1 (0.44) | MEN1KMT2A | |
| SCHEMBL8806163 | 0.82 | MEN1 (0.44) | MEN1KMT2A | |
| SCHEMBL8806666 | 0.82 | MEN1 (0.44) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673932-B1 | Sulfonamidocarbonyl-pyridine-2-carboxamides as well as their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AG (DE) | 2000-06-07 | — | — | EP | disclosed |
| EP-0673932-A1 | Sulfonamidocarbonyl-pyridine-2-carboxamides as well as their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-27 | — | — | EP | disclosed |