Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099332 | 0.90 | MEN1 (0.41) | PTGS2PTGS1EGFRP4HTMMCL1 | |
| SCHEMBL8766943 | 0.90 | PTGS2 (0.48) | PTGS2PTGS1EGFRP4HTMPKM | |
| SCHEMBL8096944 | 0.88 | SMN1; SMN2 (0.39) | PTGS2EGFRP4HTMSMN1; SMN2KMT2A | |
| SCHEMBL8090051 | 0.88 | P4HTM (0.45) | P4HTMSMN1; SMN2KMT2A | |
| SCHEMBL8099328 | 0.87 | P4HTM (0.37) | PTGS2EGFRP4HTMSMN1; SMN2NPC1 | |
| SCHEMBL8874936 | 0.86 | PTGS2 (0.46) | PTGS2PTGS1EGFRP4HTMSMN1; SMN2 | |
| SCHEMBL8768279 | 0.85 | LMNA (0.42) | SMN1; SMN2KMT2A | |
| SCHEMBL8090622 | 0.83 | SMN1; SMN2 (0.39) | SMN1; SMN2PKMKMT2A | |
| SCHEMBL8767487 | 0.82 | PTGS2 (0.55) | PTGS2PTGS1EGFRP4HTMPKM | |
| Hydrochloric Acid SCHEMBL9231980 | 0.81 | PTGS2 (0.54) | PTGS2PTGS1EGFRP4HTMPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673932-B1 | Sulfonamidocarbonyl-pyridine-2-carboxamides as well as their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AG (DE) | 2000-06-07 | — | — | EP | disclosed |
| EP-0673931-A1 | Sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-27 | — | — | EP | disclosed |
| EP-0673932-A1 | Sulfonamidocarbonyl-pyridine-2-carboxamides as well as their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-27 | — | — | EP | disclosed |