Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 5/20 | 0.68 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.68 |
| ▸ | CCR2 | P41597 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8523996 | 0.86 | CCR2 (0.60) | PTGS1PTGS2CCR2NPC1TSHR | |
| SCHEMBL8524909 | 0.86 | PTGS1 (0.54) | PTGS1PTGS2CCR2NPC1TSHR | |
| SCHEMBL8524278 | 0.83 | PTGS1 (0.51) | PTGS1PTGS2CCR2NPC1TSHR | |
| SCHEMBL6378390 | 0.83 | PTGS1 (0.56) | PTGS1PTGS2CCR2TSHRSLC6A2 | |
| SCHEMBL8091464 | 0.81 | PTGS2 (0.62) | PTGS1PTGS2CCR2TSHRSLC6A2 | |
| SCHEMBL7162523 | 0.81 | PTGS1 (0.59) | PTGS1PTGS2CCR2SLC6A2SLC6A4 | |
| SCHEMBL27698563 | 0.81 | PTGS1 (0.54) | PTGS1PTGS2CCR2NPC1TSHR | |
| SCHEMBL8107162 | 0.80 | PTGS1 (0.61) | PTGS1PTGS2CCR2SLC6A2SLC6A3 | |
| SCHEMBL9657545 | 0.80 | PTGS1 (0.61) | PTGS1PTGS2CCR2SLC6A2SLC6A4 | |
| SCHEMBL8523577 | 0.80 | PTGS1 (0.58) | PTGS1PTGS2CCR2SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848703-B1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2000-09-27 | — | — | EP | disclosed |
| US-6004948-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | NYCOMED AUSTRIA GMBH (AT) | 1999-12-21 | — | — | US | disclosed |