Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845324 | 1.00 | ALDH1A1 (0.40) | ALDH1A1HPGDCYP19A1SERPINE1EPHX1 | |
| SCHEMBL8100287 | 1.00 | ALDH1A1 (0.40) | ALDH1A1HPGDCYP19A1SERPINE1EPHX1 | |
| SCHEMBL7845327 | 0.79 | HTR1A (0.32) | — | |
| SCHEMBL7844867 | 0.78 | HTR2C (0.38) | CYP19A1 | |
| SCHEMBL7844871 | 0.78 | HTR2C (0.38) | CYP19A1 | |
| SCHEMBL6218189 | 0.69 | CYP19A1 (0.37) | ALDH1A1HPGDCYP19A1TSHRMAPK1 | |
| SCHEMBL6218185 | 0.69 | CYP19A1 (0.37) | ALDH1A1HPGDCYP19A1TSHRMAPK1 | |
| SCHEMBL7835510 | 0.69 | CYP19A1 (0.37) | ALDH1A1HPGDCYP19A1TSHRMAPK1 | |
| SCHEMBL10199136 | 0.68 | EPHX1 (0.58) | ALDH1A1HPGDCYP19A1EPHX1MAPT | |
| SCHEMBL27914203 | 0.68 | EPHX1 (0.58) | ALDH1A1HPGDCYP19A1EPHX1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046207-A | FOR INHIBITING ALPHA-1 ADRENORECEPTORS AND TREATING BENIGN PROSTATIC HYPERPLASIA, ALSO CALLED BENIGN PROSTATIC HYPERTROPHY, OR OTHER UROLOGICAL OR GYNECOLOGICAL DISEASES SUCH AS BLADDER OUTLET OBSTRUCTION, NEUROGENIC BLADDER | ABBOTT LABORATORIES | 2000-04-04 | — | — | US | disclosed |
| US-5891882-A | TREATING BENIGN PROSTATIC HYPERPLASIA OR OTHER UROLOGICAL DISEASES SUCH AS BLADDER OUTLET OBSTRUCTION AND NEUROGENIC BLADDER, OR GYNECOLOGICAL SYNDROMES SUCH AS DYSMENORRHEA | ABBOTT LABORATORIES (US) | 1999-04-06 | — | — | US | disclosed |