Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 13/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.45 |
| ▸ | GABRE | P78334 | 1/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.45 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098633 | 0.84 | PIM1 (0.49) | SLC6A4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8545772 | 0.83 | GABRP (0.45) | SLC6A4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8091126 | 0.81 | GABRP (0.56) | SLC6A4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8304104 | 0.81 | SLC6A4 (0.64) | SLC6A4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8106878 | 0.76 | GABRP (0.55) | SLC6A4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8301752 | 0.74 | IDO1 (0.53) | SLC6A4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2270899 | 0.73 | SLC6A4 (0.67) | SLC6A4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL31328282 | 0.71 | SLC6A4 (0.56) | SLC6A4HTR1AHTR2AAPPADRB2 | |
| SCHEMBL1445394 | 0.71 | GABRP (0.54) | SLC6A4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5453495 | 0.71 | SLC6A4 (0.56) | SLC6A4HTR1ADRD1SLC6A2HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942524-A | 5-arylindole derivatives | PFIZER INC. (US) | 1999-08-24 | — | — | US | claimed |
| EP-0716649-B1 | 5-ARYLINDOLE DERIVATIVES | PFIZER (US) | 1998-09-09 | — | — | EP | claimed |
| US-6093822-A | 5-arylindole derivatives | PFIZER INC. (US) | 2000-07-25 | — | — | US | disclosed |
| US-5994352-A | 5-arylindole derivatives | PFIZER INC. (US) | 1999-11-30 | — | — | US | disclosed |
| US-5942524-A | 5-arylindole derivatives | PFIZER INC. (US) | 1999-08-24 | — | — | US | disclosed |
| EP-0716649-B1 | 5-ARYLINDOLE DERIVATIVES | PFIZER (US) | 1998-09-09 | — | — | EP | disclosed |
| WO-1995006636-A1 | 5-ARYLINDOLE DERIVATIVES | PFIZER INC. (US) | 1995-03-09 | — | — | WO | disclosed |