Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | BCR | P11274 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 6/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092113 | 0.86 | PTGS2 (0.56) | PTGS2FFAR4PTGS1CA2CA1 | |
| SCHEMBL8100672 | 0.85 | SLC6A4 (0.58) | KIF11SLC6A4SLC6A3PTGS2CA2 | |
| SCHEMBL8101207 | 0.81 | PTGS2 (0.54) | SLC6A4PTGS2PTGS1CA2CA1 | |
| SCHEMBL8100934 | 0.81 | CA2 (0.44) | SLC6A4PTGS2PTGS1CA2CA1 | |
| SCHEMBL8091413 | 0.80 | PTGS2 (0.56) | SLC6A4PTGS2PTGS1CA2CA1 | |
| SCHEMBL8101193 | 0.76 | CA2 (0.43) | SLC6A4SLC6A3PTGS2PTGS1CA2 | |
| SCHEMBL8107618 | 0.73 | NR3C1 (0.42) | SLC6A4PTGS2PTGS1CA2CA1 | |
| SCHEMBL8101785 | 0.72 | CA2 (0.48) | KIF11SLC6A4SLC6A3PTGS2PTGS1 | |
| SCHEMBL1137645 | 0.71 | PTGS2 (0.65) | KIF11SLC6A4SLC6A3PTGS2FFAR4 | |
| SCHEMBL8099531 | 0.70 | CA1 (0.41) | PTGS2FFAR4CA2CA1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848703-B1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2000-09-27 | — | — | EP | disclosed |
| US-6004948-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | NYCOMED AUSTRIA GMBH (AT) | 1999-12-21 | — | — | US | disclosed |
| EP-0848703-A1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | Nycomed Austria GmbH (AT) | 1998-06-24 | — | — | EP | disclosed |
| WO-1997003953-A1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 1997-02-06 | — | — | WO | disclosed |