Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 6/20 | 0.51 |
| ▸ | CA4 | P22748 | 5/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101207 | 0.86 | PTGS2 (0.54) | PTGS2PTGS1CA2CA4CA12 | |
| SCHEMBL8100934 | 0.86 | CA2 (0.44) | PTGS2PTGS1CA2CA4CA12 | |
| SCHEMBL8107618 | 0.86 | NR3C1 (0.42) | PTGS2PTGS1CA2CA4CA12 | |
| SCHEMBL8092113 | 0.84 | PTGS2 (0.56) | PTGS2PTGS1CA2CA4CA12 | |
| SCHEMBL8100672 | 0.83 | SLC6A4 (0.58) | PTGS2CA2CA12CA1CA9 | |
| SCHEMBL8101100 | 0.83 | CA2 (0.44) | PTGS2PTGS1CA2CA12CA1 | |
| SCHEMBL8101193 | 0.82 | CA2 (0.43) | PTGS2PTGS1CA2CA4CA12 | |
| SCHEMBL28393642 | 0.81 | PTGS2 (0.59) | PTGS2PTGS1MAPTALDH1A1HPGD | |
| SCHEMBL8101145 | 0.80 | KIF11 (0.45) | PTGS2PTGS1CA2CA12CA1 | |
| SCHEMBL8100630 | 0.80 | CA2 (0.44) | PTGS2PTGS1CA2CA4CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848703-B1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2000-09-27 | — | — | EP | disclosed |
| US-6004948-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | NYCOMED AUSTRIA GMBH (AT) | 1999-12-21 | — | — | US | disclosed |
| EP-0848703-A1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | Nycomed Austria GmbH (AT) | 1998-06-24 | — | — | EP | disclosed |
| WO-1997003953-A1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 1997-02-06 | — | — | WO | disclosed |