Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | SOX18 | P35713 | 1/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101983 | 0.77 | HTR2A (0.48) | HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL5134431 | 0.75 | HTR2A (0.55) | HTR2AHTR2CHTR2BSIGMAR1SLC6A4 | |
| SCHEMBL297384 | 0.74 | ALOX5 (0.61) | ALOX5HSD17B1HSD17B2 | |
| SCHEMBL3686569 | 0.74 | IAPP (0.57) | ALOX5HSD17B1HSD17B2SOX18 | |
| SCHEMBL28326510 | 0.71 | HTR2A (0.54) | HTR2ASIGMAR1SLC6A4 | |
| SCHEMBL3358215 | 0.70 | ALOX5 (0.52) | ALOX5HSD17B1HSD17B2 | |
| SCHEMBL9068508 | 0.70 | SIGMAR1 (0.53) | HTR2AHTR2CHTR2BSIGMAR1SLC6A4 | |
| SCHEMBL4006370 | 0.69 | CYP1A2 (0.56) | HTR2ASIGMAR1SLC6A4 | |
| SCHEMBL28838293 | 0.69 | SIGMAR1 (0.56) | HTR2AHTR2CHTR2BSIGMAR1SLC6A4 | |
| SCHEMBL3665020 | 0.68 | FABP3 (0.38) | ALOX5SLC6A4HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6069177-A | ADMINISTERING TO THE HUMAN AN EFFECTIVE ANTIDEPRESSANT DOSE OF THE COMPOUND 3-HYDROXY-4,4-DIMETHYL-2-(2'-NAPHTHYL)PENTYL-N,N-DIMETHYLAMINE OR SALT | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (HK) | 2000-05-30 | — | — | US | claimed |