Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 2/20 | 0.43 |
| ▸ | CDC25A | P30304 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | PTPRC | P08575 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354968 | 0.82 | MAOA (0.50) | CDC25BCDC25AMEN1KMT2AMAPT | |
| SCHEMBL30645249 | 0.80 | CDC25B (0.47) | CDC25BCDC25AMEN1KMT2AMAPT | |
| SCHEMBL28865505 | 0.80 | CDC25A (0.48) | CDC25BCDC25AKEAP1NFE2L2MEN1 | |
| SCHEMBL27358025 | 0.77 | FGFR1 (0.46) | CDC25BCDC25AMAPTPOLBKDM4E | |
| SCHEMBL28211937 | 0.76 | MAOA (0.49) | CDC25BCDC25AMEN1KMT2AMAPT | |
| SCHEMBL2124709 | 0.76 | MEN1 (0.43) | KEAP1NFE2L2MEN1KMT2AMAPT | |
| SCHEMBL11409080 | 0.74 | CDC25B (0.50) | CDC25BCDC25AMEN1KMT2AMAPT | |
| SCHEMBL31127006 | 0.74 | CES1 (0.41) | CDC25BCDC25AMEN1KMT2AMAPT | |
| SCHEMBL10496201 | 0.73 | MEN1 (0.49) | KEAP1NFE2L2MEN1KMT2AMAPT | |
| SCHEMBL27264312 | 0.73 | CES1 (0.46) | CDC25BCDC25AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6013674-A | INDENONE AMIDE DERIVATIVES, USEFUL FOR FOR THE INHIBITION OF LEUKOCYTE ADHERENCE TO ENDOTHELIAL CELLS; USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES, AS ARTHRITIS, ASTHAMA, PSORIASIS, RESPIRATORY DISTRESS SYNDROME, STROKE AND ULCER | ELI LILLY AND COMPANY (US) | 2000-01-11 | — | — | US | disclosed |
| EP-0882706-A1 | Cell adhesion inhibitors | ELI LILLY AND COMPANY (US) | 1998-12-09 | — | — | EP | disclosed |