Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.42 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8111568 | 0.78 | ALDH1A1 (0.42) | TSHRMAPK1CYP1A2L3MBTL1CYP3A4 | |
| SCHEMBL8102779 | 0.77 | TSHR (0.49) | TSHRMAPK1PDE7APDE7BVCAM1 | |
| SCHEMBL16959573 | 0.76 | MAPK1 (0.50) | TSHRMAPK1CYP1A2PDE7APDE7B | |
| SCHEMBL4300511 | 0.76 | TSHR (0.50) | TSHRMAPK1CYP1A2VCAM1L3MBTL1 | |
| SCHEMBL8111566 | 0.76 | RECQL (0.43) | TSHRMAPK1CYP1A2L3MBTL1CYP3A4 | |
| SCHEMBL27368186 | 0.75 | MAPK1 (0.46) | TSHRMAPK1CYP1A2PDE7APDE7B | |
| SCHEMBL8102532 | 0.74 | ALDH1A1 (0.54) | TSHRMAPK1PDE7AL3MBTL1CYP3A4 | |
| SCHEMBL5583389 | 0.74 | MAPK1 (0.49) | TSHRMAPK1CYP1A2PDE7APDE7B | |
| SCHEMBL3253882 | 0.73 | TSHR (0.51) | TSHRMAPK1PDE7APDE7BVCAM1 | |
| SCHEMBL16971145 | 0.71 | CYP1A2 (0.49) | TSHRMAPK1CYP1A2CYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0645378-B1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-08-23 | — | — | EP | disclosed |
| CN-1054380-C | Condensed cyclic compounds and their use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-07-12 | — | — | CN | disclosed |
| US-5698691-A | ANTICHOLESTEROL AGENT; SYNTHETASE INHIBITOR; FUNGICIDE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0645378-A1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | Takeda Chemical Industries, Ltd. (JP) | 1995-03-29 | — | — | EP | disclosed |