Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | PDE7A | Q13946 | 8/20 | 0.40 |
| ▸ | PDE7B | Q9NP56 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8102722 | 0.77 | TSHR (0.47) | TSHRMAPK1PDE7APDE7BL3MBTL1 | |
| SCHEMBL7727749 | 0.76 | ACP3 (0.41) | TSHRMAPK1L3MBTL1LMNAALDH1A1 | |
| SCHEMBL16958911 | 0.73 | MAPK1 (0.53) | TSHRMAPK1PDE7APDE7BL3MBTL1 | |
| SCHEMBL8102532 | 0.73 | ALDH1A1 (0.54) | TSHRMAPK1PDE7AL3MBTL1LMNA | |
| SCHEMBL3253882 | 0.71 | TSHR (0.51) | TSHRMAPK1PDE7APDE7BL3MBTL1 | |
| SCHEMBL13875029 | 0.71 | MAPK1 (0.58) | TSHRMAPK1PDE7APDE7BL3MBTL1 | |
| SCHEMBL2119495 | 0.71 | MAPK1 (0.58) | TSHRMAPK1PDE7APDE7BL3MBTL1 | |
| SCHEMBL3663698 | 0.71 | CNR1 (0.53) | TSHRMAPK1L3MBTL1LMNAALDH1A1 | |
| SCHEMBL27368186 | 0.70 | MAPK1 (0.46) | TSHRMAPK1PDE7APDE7BL3MBTL1 | |
| SCHEMBL5583389 | 0.70 | MAPK1 (0.49) | TSHRMAPK1PDE7APDE7BL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0645378-B1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-08-23 | — | — | EP | disclosed |
| CN-1054380-C | Condensed cyclic compounds and their use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-07-12 | — | — | CN | disclosed |
| US-5698691-A | ANTICHOLESTEROL AGENT; SYNTHETASE INHIBITOR; FUNGICIDE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| CN-1106397-A | Condensed cyclic compounds and their use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-08-09 | — | — | CN | disclosed |
| EP-0645378-A1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | Takeda Chemical Industries, Ltd. (JP) | 1995-03-29 | — | — | EP | disclosed |