Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5801377 | 0.84 | LMNA (0.47) | ALDH1A1MAPK1TDP1LMNAMAPT | |
| SCHEMBL23536629 | 0.81 | ALDH1A1 (0.55) | ALDH1A1MAPK1LMNAPKMAPP | |
| SCHEMBL7684242 | 0.80 | ALDH1A1 (0.64) | ALDH1A1MAPK1TSHRTDP1LMNA | |
| SCHEMBL948375 | 0.79 | ALDH1A1 (0.51) | ALDH1A1MAPK1TSHRTDP1LMNA | |
| SCHEMBL8111568 | 0.77 | ALDH1A1 (0.42) | ALDH1A1MAPK1TSHRTDP1LMNA | |
| SCHEMBL4850984 | 0.75 | ALDH1A1 (0.47) | ALDH1A1MAPK1TSHRTDP1LMNA | |
| SCHEMBL8102722 | 0.74 | TSHR (0.47) | ALDH1A1MAPK1TSHRLMNAPDE7A | |
| SCHEMBL8102779 | 0.73 | TSHR (0.49) | ALDH1A1MAPK1TSHRLMNAPDE7A | |
| SCHEMBL4308070 | 0.72 | ALDH1A1 (0.46) | ALDH1A1MAPK1TSHRTDP1LMNA | |
| SCHEMBL624054 | 0.72 | ALDH1A1 (0.64) | ALDH1A1MAPK1TSHRTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0645378-B1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-08-23 | — | — | EP | disclosed |
| CN-1054380-C | Condensed cyclic compounds and their use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-07-12 | — | — | CN | disclosed |
| US-5698691-A | ANTICHOLESTEROL AGENT; SYNTHETASE INHIBITOR; FUNGICIDE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| CN-1106397-A | Condensed cyclic compounds and their use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-08-09 | — | — | CN | disclosed |
| EP-0645378-A1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | Takeda Chemical Industries, Ltd. (JP) | 1995-03-29 | — | — | EP | disclosed |