Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TPMT | P51580 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8354895 | 0.86 | CA2 (0.41) | TPMTHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL14104505 | 0.78 | LMNA (0.49) | LMNAHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL10370336 | 0.78 | TPMT (0.51) | LMNATPMTHSD17B10KDM4EALDH1A1 | |
| SCHEMBL24837048 | 0.76 | TPMT (0.50) | TPMTHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL27598922 | 0.75 | KDM4E (0.53) | LMNATPMTHSD17B10KDM4EALDH1A1 | |
| SCHEMBL8354879 | 0.74 | LMNA (0.42) | LMNAHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL1815665 | 0.73 | LMNA (0.64) | LMNAHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL1018520 | 0.73 | LMNA (0.59) | LMNAHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL25284670 | 0.71 | LMNA (0.57) | LMNAHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL27263689 | 0.71 | LMNA (0.56) | LMNAHSD17B10KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0814077-B1 | Benzoylguanidines, process for their preparation and medicaments containing them | HOECHST AG (DE) | 2000-04-05 | — | — | EP | disclosed |
| US-6001881-A | Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |
| EP-0814077-A1 | Benzoylguanidines, process for their preparation and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-29 | — | — | EP | disclosed |