Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TPMT | P51580 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8102925 | 0.86 | LMNA (0.45) | KDM4EALDH1A1HPGDPOLBTPMT | |
| SCHEMBL3215571 | 0.83 | KDM4E (0.38) | CA2KDM4EALDH1A1POLBHSD17B10 | |
| SCHEMBL8356473 | 0.83 | MAPT (0.38) | CA2KDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL8354928 | 0.81 | ALDH1A1 (0.42) | CA2KDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL8354876 | 0.80 | KDM4E (0.39) | CA2KDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL1530644 | 0.78 | KDM4E (0.45) | CA2KDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL1017860 | 0.78 | KDM4E (0.45) | CA2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1809801 | 0.78 | LMNA (0.46) | CA2KDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL24837041 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1HPGDNPSR1POLB | |
| SCHEMBL7824006 | 0.76 | KMT2A (0.44) | CA2KDM4EALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001881-A | Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |