Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358621 | 0.88 | CA2 (0.39) | LMNAKDM4ENPSR1HSD17B10POLB | |
| SCHEMBL8358558 | 0.82 | LMNA (0.45) | LMNAACE2KDM4EPOLBMAPK1 | |
| SCHEMBL8088976 | 0.81 | LMNA (0.32) | LMNA | |
| SCHEMBL8350665 | 0.81 | LMNA (0.51) | LMNAACE2MAPTALDH1A1PTGDR2 | |
| SCHEMBL8358390 | 0.76 | ALDH1A1 (0.38) | LMNAKDM4EHSD17B10MAPTALDH1A1 | |
| SCHEMBL8358401 | 0.75 | ALDH1A1 (0.42) | LMNAKDM4EHSD17B10MAPTALDH1A1 | |
| SCHEMBL8102925 | 0.74 | LMNA (0.45) | LMNAKDM4EHSD17B10POLBMAPK1 | |
| SCHEMBL8097729 | 0.66 | SLC9A1 (0.30) | LMNA | |
| SCHEMBL8089448 | 0.65 | LMNA (0.35) | LMNAMAPTALDH1A1 | |
| SCHEMBL27263689 | 0.65 | LMNA (0.56) | LMNAKDM4EHSD17B10MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001881-A | Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |