Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 3/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | NQO2 | P16083 | 7/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8841007 | 1.00 | SRD5A1 (0.54) | SRD5A1MTNR1ASIGMAR1NQO2MTNR1B | |
| SCHEMBL8840972 | 1.00 | SRD5A1 (0.54) | SRD5A1MTNR1ASIGMAR1NQO2MTNR1B | |
| SCHEMBL7797824 | 0.89 | SRD5A1 (0.65) | SRD5A1HTR2CCYP19A1 | |
| SCHEMBL7797820 | 0.89 | SRD5A1 (0.65) | SRD5A1HTR2CCYP19A1 | |
| SCHEMBL12307952 | 0.78 | MTNR1A (0.44) | MTNR1ANQO2MTNR1BHTR2AHTR2C | |
| SCHEMBL10650500 | 0.78 | DRD2 (0.43) | SRD5A1MTNR1ASIGMAR1HTR2BCYP19A1 | |
| SCHEMBL8898725 | 0.77 | ACHE (0.48) | HTR2AHTR2CHTR2B | |
| SCHEMBL1871938 | 0.77 | HSD11B1 (0.56) | SIGMAR1HTR2AHTR2CHTR2BCHRNA7 | |
| SCHEMBL9964003 | 0.77 | HSD11B1 (0.56) | SIGMAR1HTR2AHTR2CHTR2BCHRNA7 | |
| SCHEMBL1869361 | 0.77 | HSD11B1 (0.56) | SIGMAR1HTR2AHTR2CHTR2BCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686637-B1 | Tetracyclic 1,4-oxazine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-04-26 | — | — | EP | disclosed |
| EP-0686637-A1 | Tetracyclic 1,4-oxazine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-12-13 | — | — | EP | disclosed |