Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 4/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.32 |
| ▸ | PPOX | P50336 | 1/20 | 0.32 |
| ▸ | S100A4 | P26447 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 2/20 | 0.30 |
| ▸ | XDH | P47989 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL705941 | 0.82 | HSD11B1 (0.44) | NPBWR1NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL3416087 | 0.79 | IDO1 (0.32) | IDO1HSD11B1PPOXS100A4PIM1 | |
| SCHEMBL1197908 | 0.79 | NOTUM (0.45) | NPBWR1HPGDIDO1HSD11B1 | |
| SCHEMBL1308358 | 0.79 | IDO1 (0.41) | HPGDRAB9ASMN1; SMN2HSD17B10IDO1 | |
| SCHEMBL23088225 | 0.79 | MEN1 (0.30) | HPGDSMN1; SMN2IDO1 | |
| SCHEMBL29792715 | 0.79 | MEN1 (0.30) | HPGDSMN1; SMN2IDO1 | |
| SCHEMBL5815364 | 0.79 | ALDH1A1 (0.49) | HPGDSMN1; SMN2IDO1PIM1 | |
| SCHEMBL5676619 | 0.77 | LMNA (0.40) | IDO1HSD11B1PPOXS100A4PIM1 | |
| SCHEMBL6816520 | 0.77 | PRMT5 (0.36) | HPGDGPR35PTGESXDH | |
| SCHEMBL1463479 | 0.76 | IDO1 (0.57) | HPGDSMN1; SMN2HSD17B10IDO1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019410-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2000-07-19 | — | — | EP | disclosed |
| WO-1997019084-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |