Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 5/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL705941 | 0.85 | HSD11B1 (0.44) | ALDH1A1MAPTCXCR2TP53HPGD | |
| SCHEMBL5676619 | 0.84 | LMNA (0.40) | ALDH1A1RXFP1IDO1PIM1TGM2 | |
| SCHEMBL24690273 | 0.82 | CYP3A4 (0.41) | ALDH1A1RXFP1HTR2BPDE4DMAPT | |
| SCHEMBL1463479 | 0.82 | IDO1 (0.57) | ALDH1A1RXFP1IDO1HTR2BPDE4D | |
| SCHEMBL1197908 | 0.79 | NOTUM (0.45) | IDO1MAPTHPGD | |
| SCHEMBL3416087 | 0.79 | IDO1 (0.32) | IDO1CXCR2PIM1 | |
| SCHEMBL1308358 | 0.79 | IDO1 (0.41) | ALDH1A1IDO1TP53HPGDSMN1; SMN2 | |
| SCHEMBL8103412 | 0.79 | NPBWR1 (0.40) | IDO1PIM1HPGDSMN1; SMN2 | |
| SCHEMBL24416907 | 0.78 | TDP1 (0.44) | ALDH1A1IDO1MAPTPIM1TGM2 | |
| SCHEMBL13259099 | 0.78 | ALDH1A1 (0.36) | ALDH1A1RXFP1HTR2BMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060211739-A1 | Use of selective P2X7 receptor antagonists | ABBOTT LABORATORIES | 2006-09-21 | — | — | US | disclosed |
| WO-2006086229-A1 | THE USE OF SELECTIVE P2X7 RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2006-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211739-A1 | Use of selective P2X7 receptor antagonists | P2RX1, P2RX3, P2RX7 | ALDH1A1 810/4885RXFP1 82/4885IDO1 1534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.