Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8894806 | 0.83 | KMT2A (0.43) | KMT2AMEN1FKBP1AEPHX1ALDH1A1 | |
| SCHEMBL8103699 | 0.79 | STAT3 (0.41) | KMT2AMEN1FKBP1AALDH1A1L3MBTL1 | |
| SCHEMBL13560888 | 0.76 | MEN1 (0.51) | KMT2AMEN1EPHX1CTSD | |
| Cyclohexane Propionic Acid SCHEMBL8121720 | 0.73 | MEN1 (0.60) | KMT2AMEN1FKBP1AEPHX1PPARG | |
| SCHEMBL2632591 | 0.72 | MEN1 (0.57) | KMT2AMEN1EPHX1POLB | |
| SCHEMBL6779971 | 0.71 | LMNA (0.56) | — | |
| SCHEMBL8121723 | 0.70 | MEN1 (0.58) | KMT2AMEN1EPHX1ALDH1A1 | |
| SCHEMBL23417577 | 0.69 | MEN1 (0.67) | KMT2AMEN1EPHX1ALDH1A1POLB | |
| SCHEMBL7045269 | 0.68 | SLC15A1 (0.45) | ALDH1A1L3MBTL1 | |
| SCHEMBL7045267 | 0.68 | SLC15A1 (0.45) | ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733642-B1 | Benzazepin-, benzoxazepin- and benzothiazepin-N-acetic acid-derivatives, their preparation and their pharmaceutical compositions | SOLVAY PHARM GMBH (DE) | 2000-11-29 | — | — | EP | disclosed |
| EP-0733642-A1 | Benzazepin-, benzoxazepin- and benzothiazepin-N-acetic acid-derivatives, their preparation and their pharmaceutical compositions | Kali-Chemie Pharma GmbH (DE) | 1996-09-25 | — | — | EP | disclosed |