Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | S100B | P04271 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18927384 | 0.77 | ALDH1A1 (0.53) | KDM4EALDH1A1KMT2ATSHRHTT | |
| SCHEMBL7983553 | 0.75 | S100B (0.44) | PDE3BPDE3AKDM4ES100BALDH1A1 | |
| SCHEMBL28963207 | 0.72 | PDE3B (0.58) | PDE3BPDE3AKDM4EALDH1A1GSK3B | |
| SCHEMBL27991756 | 0.69 | PDE3B (0.48) | PDE3BPDE3AKDM4EALDH1A1GSK3B | |
| SCHEMBL7710952 | 0.67 | KDM4E (0.58) | KDM4EALDH1A1KMT2ATSHRHTT | |
| SCHEMBL13153946 | 0.67 | MEN1 (0.46) | PDE3BPDE3AKDM4ES100BALDH1A1 | |
| SCHEMBL22418007 | 0.64 | KDM4E (0.48) | KDM4EALDH1A1TSHRHTTLMNA | |
| SCHEMBL1003108 | 0.63 | NQO2 (0.63) | PDE3BPDE3AKDM4ES100BALDH1A1 | |
| SCHEMBL30929112 | 0.62 | PDE10A (0.43) | KDM4ES100BALDH1A1KMT2ARET | |
| SCHEMBL7854123 | 0.62 | PDE3B (0.49) | PDE3BPDE3AKDM4ES100BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114373-A | ADMINISTERING 6-METHOXYMELATONIN TO TREAT FREE RADICAL RELATED DISEASES SUCH AS ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, HEART DISEASE, CANCER, AND TO SLOW THE AGING PROCESS | TAN DUN-XIAN (US) | 2000-09-05 | — | — | US | disclosed |