SCHEMBL810405

SCHEMBL810405

N#CN=C(NCCCCCCNC(=O)c1ccccc1)Nc1ccncc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
JAK2 O60674 1/20 0.50
TYK2 P29597 1/20 0.50
NAAA Q02083 2/20 0.48
HDAC3 O15379 4/20 0.47
HDAC1 Q13547 4/20 0.47
HDAC6 Q9UBN7 4/20 0.47
HDAC4 P56524 3/20 0.47
HDAC7 Q8WUI4 3/20 0.47
HDAC2 Q92769 3/20 0.47
HDAC10 Q969S8 3/20 0.47
HDAC11 Q96DB2 3/20 0.47
HDAC8 Q9BY41 3/20 0.47
HDAC9 Q9UKV0 3/20 0.47
HDAC5 Q9UQL6 3/20 0.47
POLB P06746 1/20 0.46
STAT3 P40763 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL810378 0.89 IKBKB (0.56) CYP1A2CYP2C9CYP2C19NAAAHDAC3
SCHEMBL30142965 0.86 SMN1; SMN2 (0.51) HDAC3HDAC1HDAC6HDAC4HDAC7
SCHEMBL20095475 0.85 CYP1A2 (0.53) CYP1A2CYP2C9CYP2C19HDAC3HDAC1
SCHEMBL7098728 0.85 CYP1A2 (0.53) CYP1A2CYP2C9CYP2C19HDAC3HDAC1
SCHEMBL2550296 0.81 SIGMAR1 (0.46) ALDH1A1NAMPT
SCHEMBL25642148 0.81 SIGMAR1 (0.46) ALDH1A1NAMPT
SCHEMBL2550291 0.81 SIGMAR1 (0.46) ALDH1A1NAMPT
SCHEMBL20095479 0.81 IKBKB (0.50) CYP1A2CYP2C9CYP2C19NAAAHDAC1
SCHEMBL2552769 0.80 SIGMAR1 (0.47) ALDH1A1NAMPT
SCHEMBL2552771 0.80 SIGMAR1 (0.47) ALDH1A1NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0984938-B1 CYANOGUANIDINES AS CELL PROLIFERATION INHIBITORS LEO PHARMA AS WITH SECONDARY N (DK) 2003-09-10 EP claimed
EP-2394649-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDYL CYANOGUANIDINES, PREPARATION METHODS AND USES THEREOF Tianjin Hemay Bio-Tech Co., Ltd. (CN) 2011-12-14 EP disclosed