Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | FRK | P42685 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.48 |
| ▸ | PTGIR | P43119 | 4/20 | 0.47 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104120 | 0.89 | PTGS2 (0.65) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL8113629 | 0.88 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL8112876 | 0.85 | PTGS2 (0.70) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL8113995 | 0.83 | FAAH (0.53) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL9192919 | 0.78 | PTGS2 (0.59) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL8104256 | 0.74 | FAAH (0.63) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| Azelaic Acid SCHEMBL9777688 | 0.73 | LMNA (0.55) | LMNAMAPTALDH1A1 | |
| SCHEMBL6745959 | 0.73 | LMNA (0.55) | LMNAMAPTALDH1A1 | |
| Sebacic Acid SCHEMBL6745956 | 0.73 | LMNA (0.55) | LMNAMAPTALDH1A1 | |
| SCHEMBL8113557 | 0.73 | FAAH (0.56) | PTGIR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626969-B1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2000-05-24 | — | — | EP | disclosed |
| US-5663053-A | COENZYME A TRANSACYLASE FOR SCREENING | SMITHKLINE BEECHAM CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5648373-A | CoA-IT and PAF inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-15 | — | — | US | disclosed |
| EP-0626969-A4 | CoA-IT AND PAF INHIBITORS. | SMITHKLINE BEECHAM CORP (US) | 1995-04-19 | — | — | EP | disclosed |
| EP-0626969-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-07 | — | — | EP | disclosed |
| WO-1993016674-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-02 | — | — | WO | disclosed |
| EP-0550502-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992004330-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-03-19 | — | — | WO | disclosed |