Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.62 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.62 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.47 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | FRK | P42685 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.47 |
| ▸ | PTGIR | P43119 | 4/20 | 0.46 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104084 | 0.88 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL8104120 | 0.88 | PTGS2 (0.65) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL8112876 | 0.84 | PTGS2 (0.70) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL8118770 | 0.83 | FAAH (0.53) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL9192919 | 0.77 | PTGS2 (0.59) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL8104256 | 0.73 | FAAH (0.63) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL8113995 | 0.72 | FAAH (0.53) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL8113890 | 0.72 | FAAH (0.51) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL1387455 | 0.71 | MAPK14 (0.86) | MAPK14MAPK13MAPK12MAPK11MAP4K4 | |
| SCHEMBL8113496 | 0.71 | PTGS2 (0.58) | MAPK14MAPK13MAPK12MAPK11PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626969-B1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2000-05-24 | — | — | EP | disclosed |
| US-5663053-A | COENZYME A TRANSACYLASE FOR SCREENING | SMITHKLINE BEECHAM CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5648373-A | CoA-IT and PAF inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-15 | — | — | US | disclosed |