Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 6/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3229576 | 0.82 | ELANE (0.46) | SIRT1POLBALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL6543433 | 0.82 | HSD17B10 (0.45) | SIRT1APAF1POLBMAPTHSD17B10 | |
| SCHEMBL5180445 | 0.80 | ELANE (0.51) | MAPTHSD17B10HTR7ALDH1A1KDM4E | |
| SCHEMBL9246592 | 0.73 | CDK1 (0.44) | ALDH1A1KDM4E | |
| SCHEMBL992746 | 0.68 | MAPT (0.45) | SIRT1APAF1POLBMAPTHSD17B10 | |
| SCHEMBL2903308 | 0.68 | KMT2A (0.41) | MAPTHSD17B10ALDH1A1KDM4ETSHR | |
| SCHEMBL1942272 | 0.66 | LMNA (0.37) | — | |
| SCHEMBL12621700 | 0.65 | ESR2 (0.43) | SIRT1APAF1POLBMAPTHSD17B10 | |
| SCHEMBL7709533 | 0.63 | TSHR (0.54) | POLBMAPTALDH1A1KDM4ETSHR | |
| SCHEMBL488467 | 0.63 | ESR2 (0.42) | SIRT1APAF1POLBMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6160124-A | Method for treating or preventing arteriosclerosis | JAPAN TOBACCO INC. (JP) | 2000-12-12 | — | — | US | disclosed |
| US-6057343-A | HAVE SUPERIOR HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIONS AND ARE USEFUL FOR THE TREATMENT OF DIABETES AND THE COMPLICATIONS THEREOF, AS WELL AS THERAPEUTIC AGENTS FOR RELATED DISEASES SUCH AS HYPERLIPIDEMIA | JAPAN TOBACCO, INC. (JP) | 2000-05-02 | — | — | US | disclosed |
| US-6037359-A | ARTERIOSCLEROSIS PREVENTION; ANTIDIABETIC AGENTS; ANTILIPEMIC AND HYPOGLYCEMIC AGENTS | JAPAN TOBACCO, INC. (JP) | 2000-03-14 | — | — | US | disclosed |
| US-5939445-A | ISOXAZOLIDINEDIONES COMPOUNDS AS HYPOGLYCEMIC AGENTS AND TREATMENT OF ARTERIOSCLEROSIS | JAPAN TOBACCO, INC. (JP) | 1999-08-17 | — | — | US | disclosed |
| EP-0684242-B1 | ISOXAZOLIDINEDIONE DERIVATIVE AND USE THEREOF | JAPAN TOBACCO INC (JP) | 1999-05-06 | — | — | EP | disclosed |
| US-5728720-A | HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; TREATMENT OF DIABETES | JAPAN TOBACCO INC. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0684242-A1 | ISOXAZOLIDINEDIONE DERIVATIVE AND USE THEREOF | JAPAN TOBACCO INC. (JP) | 1995-11-29 | — | — | EP | disclosed |
| US-4276401-A | N-Heterocyclic substituted acryloyl polymeric compounds | CIBA-GEIGY CORPORATION (US) | 1981-06-30 | — | — | US | disclosed |
| US-4012399-A | ULTRAVIOLET LIGHT ABSORBERS AND STABILIZERS | CINCINNATI MILACRON CHEMICALS, INC. (US) | 1977-03-15 | — | — | US | disclosed |
| US-4000101-A | POLYPROPYLENE | WESTON CHEMICAL CORPORATION (US) | 1976-12-28 | — | — | US | disclosed |
| US-3959220-A | Polymer additives comprising transition metal complexes with trivalent phosphorous compounds | CINCINNATI MILACRON CHEMICALS, INC. (US) | 1976-05-25 | — | — | US | disclosed |