Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9545924 | 0.83 | HTR7 (0.41) | TRPA1 | |
| SCHEMBL15636516 | 0.81 | CYP2A6 (0.42) | TRPA1DPP4 | |
| SCHEMBL29144747 | 0.79 | TRPA1 (0.40) | TRPA1ALOX5APFEN1GABRA1GABRB2 | |
| SCHEMBL28684935 | 0.79 | TRPA1 (0.40) | TRPA1ALOX5APFEN1CSNK2A2CSNK2B | |
| SCHEMBL8913076 | 0.79 | HTR7 (0.46) | PTPN5DHFR | |
| SCHEMBL1370479 | 0.78 | ALDH1A1 (0.36) | ALDH1A1MAPTMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL533409 | 0.76 | DPP4 (0.42) | TRPA1ALOX5APFEN1CSNK2A2CSNK2B | |
| SCHEMBL11647426 | 0.75 | PTGER1 (0.53) | TRPA1ALOX5APFEN1CSNK2A2CSNK2B | |
| SCHEMBL15063779 | 0.74 | TRPA1 (0.41) | TRPA1ALOX5APFEN1CSNK2A2CSNK2B | |
| SCHEMBL328862 | 0.71 | DPP4 (0.60) | TRPA1GABRA1GABRB2PTGER1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133276-A | A LIGAND INHIBITOR OF A CRF/CRF-BINDING PROTEIN COMPLEX TO EFFECT INCREASED LEVELS OF CRF; 2,4-DIOXO- OR 2-THIOCARBONYL-4-OXO-5-(HYDROCARBYL(THIO)CARBONYLAMINOMETHYL)-6-HYDROXY-HEXA-HEXAHYDROPYRIMIDINES; ALZHEIMER'S, OBESITY; LOW SIDE EFFECTS | NEUROCRINE BIOSCIENCES, INC. (US) | 2000-10-17 | — | — | US | disclosed |
| US-5959109-A | A LIGAND INHIBITOR CAUSES RELASES OF CORTICOTROPIN-RELEASING FACTOR FROM THE CORTICOTROPIN/CORTICOTROPIN-BINDING PROTEIN COMPLEX, PROVIDES IMPROVEMENT IN LEARNING AND MEMORY | NEUROCRINE BIOSCIENCES, INC. (US) | 1999-09-28 | — | — | US | disclosed |