Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5957736 | 0.89 | PTPN1 (0.52) | PTPN1FFAR4LMNAHPGDPTGER1 | |
| SCHEMBL1539870 | 0.84 | MAPT (0.59) | PTPN1HTTGAAFFAR4LMNA | |
| SCHEMBL8105424 | 0.79 | MAPK1 (0.46) | PTPN1KDM4EHPGDMAPTSMN1; SMN2 | |
| SCHEMBL5958152 | 0.77 | PTPN1 (0.52) | PTPN1FFAR4LMNAHPGDCYP2C9 | |
| SCHEMBL12379065 | 0.77 | PTGER1 (0.53) | PTPN1FFAR4LMNAHPGDCYP2C9 | |
| SCHEMBL1539863 | 0.77 | PTPN1 (0.54) | PTPN1FFAR4LMNAHPGDCYP2C9 | |
| SCHEMBL9702017 | 0.76 | PPARA (0.55) | PTPN1FFAR4CYP2C9SMN1; SMN2TDP1 | |
| SCHEMBL16075023 | 0.76 | MAPT (0.54) | PTPN1HTTFFAR4LMNAHPGD | |
| SCHEMBL5957872 | 0.75 | LMNA (0.51) | PTPN1GAAFFAR4LMNAHPGD | |
| SCHEMBL12379069 | 0.75 | GLRA1 (0.52) | PTPN1KDM4EFFAR4LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027335-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | Cerebrus Pharmaceuticals Limited (GB) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999023075-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | CEREBRUS PHARMACEUTICALS LIMITED (GB) | 1999-05-14 | — | — | WO | disclosed |