Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1539870 | 0.88 | MAPT (0.59) | MAPK1MAPTTDP1L3MBTL1HPGD | |
| SCHEMBL8105002 | 0.79 | PTPN1 (0.50) | MAPK1MAPTTDP1L3MBTL1HPGD | |
| SCHEMBL5957736 | 0.78 | PTPN1 (0.52) | L3MBTL1HPGDSMN1; SMN2PTPN1POLB | |
| SCHEMBL9702017 | 0.77 | PPARA (0.55) | TDP1SMN1; SMN2ADRA1APTPN1TSHR | |
| SCHEMBL16075023 | 0.76 | MAPT (0.54) | MAPK1MAPTTDP1L3MBTL1HPGD | |
| SCHEMBL7141620 | 0.76 | KDM4E (0.69) | MAPK1MAPTTDP1L3MBTL1HPGD | |
| SCHEMBL5957872 | 0.75 | LMNA (0.51) | MAPK1MAPTTDP1L3MBTL1HPGD | |
| SCHEMBL24968079 | 0.75 | L3MBTL1 (0.63) | MAPK1MAPTTDP1L3MBTL1HPGD | |
| SCHEMBL24372040 | 0.74 | MAOB (0.51) | MAPK1MAPTTDP1L3MBTL1HPGD | |
| SCHEMBL8114284 | 0.74 | MEN1 (0.61) | MAPTHPGDSMN1; SMN2PTPN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027335-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | Cerebrus Pharmaceuticals Limited (GB) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999023075-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | CEREBRUS PHARMACEUTICALS LIMITED (GB) | 1999-05-14 | — | — | WO | disclosed |