Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 3/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | BRS3 | P32247 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.42 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205311 | 0.83 | HNF4A (0.45) | MMP1MMP2MMP9MMP12KDM4A | |
| SCHEMBL8122044 | 0.80 | MMP1 (0.51) | MMP1MMP12DAODHODH | |
| SCHEMBL4380912 | 0.79 | HCAR2 (0.54) | HCAR2MMP1MMP2MMP9MMP12 | |
| SCHEMBL6473197 | 0.78 | KDM4E (0.47) | MMP1MMP2MMP9MMP12ALOX5 | |
| SCHEMBL14603936 | 0.73 | HCAR2 (0.54) | HCAR2MMP1MMP2MMP9MMP12 | |
| SCHEMBL5367116 | 0.73 | HCAR2 (0.50) | HCAR2PDE3BPDE3ABRS3CTBP2 | |
| SCHEMBL7374000 | 0.73 | TSHR (0.57) | HCAR2BRS3CTBP2DCLRE1BRXRA | |
| SCHEMBL10891486 | 0.71 | PIK3CA (0.56) | HCAR2MMP9PIK3CACTBP2DCLRE1B | |
| SCHEMBL11322770 | 0.71 | PTPN1 (0.51) | HCAR2PIK3CACTBP2APEX1 | |
| SCHEMBL401142 | 0.70 | PDE5A (0.64) | HCAR2PDE5APDE3BPDE3ABRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019391-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999018096-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-04-15 | — | — | WO | disclosed |