Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8121502 | 1.00 | ALDH1A1 (0.45) | ALDH1A1NPSR1LMNAL3MBTL1MAPT | |
| SCHEMBL18406191 | 0.77 | LMNA (0.51) | ALDH1A1NPSR1LMNAL3MBTL1MAPT | |
| SCHEMBL30148110 | 0.76 | ALDH1A1 (0.46) | ALDH1A1NPSR1LMNAL3MBTL1TSHR | |
| SCHEMBL2139057 | 0.76 | HSD17B10 (0.44) | ALDH1A1NPSR1LMNAL3MBTL1MAPT | |
| SCHEMBL19777235 | 0.75 | ALDH1A1 (0.45) | ALDH1A1NPSR1LMNAL3MBTL1MAPT | |
| SCHEMBL8121446 | 0.75 | CHRNB2 (0.56) | ALDH1A1NPSR1LMNAL3MBTL1MAPT | |
| SCHEMBL17069024 | 0.75 | EPHX2 (0.53) | ALDH1A1NPSR1LMNAL3MBTL1MAPT | |
| SCHEMBL16482378 | 0.75 | ALDH1A1 (0.45) | ALDH1A1NPSR1LMNAL3MBTL1MAPT | |
| SCHEMBL8114296 | 0.75 | CHRNB2 (0.56) | ALDH1A1NPSR1LMNAL3MBTL1MAPT | |
| SCHEMBL17069033 | 0.74 | ALDH1A1 (0.49) | ALDH1A1NPSR1LMNAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588917-B1 | ISOXAZOLE AND ISOTHIAZOLE COMPOUNDS THAT ENHANCE COGNITIVE FUNCTION | ABBOTT LAB (US) | 2000-11-08 | — | — | EP | disclosed |
| US-5409946-A | Antiepileptic agent | ABBOTT LABORATORIES (US) | 1995-04-25 | — | — | US | disclosed |