Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101672 | 0.87 | KDM4E (0.65) | RAB9ANPC1KMT2AMEN1CASP3 | |
| SCHEMBL1659994 | 0.85 | KDM4E (0.52) | RAB9ANPC1KMT2AMEN1KDM4E | |
| SCHEMBL28958139 | 0.83 | KDM5B (0.50) | KMT2AMEN1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8099803 | 0.83 | NPC1 (0.51) | RAB9ANPC1KMT2AMEN1CASP3 | |
| SCHEMBL31365868 | 0.83 | KDM5B (0.50) | KMT2AMEN1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8100175 | 0.83 | GRM5 (0.55) | RAB9ANPC1KMT2AMEN1CASP3 | |
| SCHEMBL7925220 | 0.82 | MEN1 (0.57) | RAB9ANPC1KMT2AMEN1KDM4E | |
| SCHEMBL16375038 | 0.80 | KDM4E (0.49) | RAB9ANPC1KMT2AMEN1CASP3 | |
| SCHEMBL8099804 | 0.79 | RAB9A (0.49) | RAB9ANPC1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1661610 | 0.79 | KDM4E (0.62) | RAB9ANPC1KMT2AMEN1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071930-A | FOR INHIBITION OF MITOSIS OR TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-06-06 | — | — | US | disclosed |
| US-5994367-A | PREVENT CELL MITOSIS; ANTICARCINOGENIC AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-11-30 | — | — | US | disclosed |