Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 9/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14081578 | 0.84 | CHRM1 (0.56) | CHRM1CHRM4CHRM5 | |
| SCHEMBL7458682 | 0.81 | CHRM1 (0.44) | CHRM1CHRM4CHRM5SLC6A4 | |
| SCHEMBL12124107 | 0.78 | HRH3 (0.47) | SLC6A4DRD2SLC6A3 | |
| SCHEMBL1335601 | 0.78 | HRH3 (0.47) | SLC6A4DRD2SLC6A3 | |
| SCHEMBL8106540 | 0.75 | SLC6A4 (0.54) | SLC6A4DRD2SLC6A3 | |
| SCHEMBL6577183 | 0.72 | OPRM1 (0.48) | SLC6A4DRD2SLC6A3 | |
| SCHEMBL4139034 | 0.71 | SLC6A4 (0.48) | SLC6A4SLC6A3 | |
| SCHEMBL4139032 | 0.71 | SLC6A4 (0.48) | SLC6A4SLC6A3 | |
| SCHEMBL7959172 | 0.71 | DRD2 (0.62) | SLC6A4DRD2 | |
| SCHEMBL8108159 | 0.71 | SLC6A4 (0.44) | SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6107307-A | PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0969005-A1 | Azabicyclic inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1999065492-A1 | INHIBITION OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |