Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.62 |
| ▸ | CTSL | P07711 | 4/20 | 0.61 |
| ▸ | CTSK | P43235 | 2/20 | 0.61 |
| ▸ | CTSB | P07858 | 2/20 | 0.61 |
| ▸ | CTSS | P25774 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | TACR1 | P25103 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KYNU | Q16719 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13287085 | 1.00 | ALDH1A1 (0.63) | ALDH1A1ALOX15CAPN1CTSLCTSK | |
| SCHEMBL9545976 | 0.94 | CTSL (0.69) | ALDH1A1ALOX15CAPN1CTSLCTSK | |
| SCHEMBL8100468 | 0.91 | CTSL (0.62) | ALDH1A1ALOX15CAPN1CTSLCTSK | |
| SCHEMBL13287011 | 0.91 | CTSL (0.62) | ALDH1A1ALOX15CAPN1CTSLCTSK | |
| SCHEMBL7151822 | 0.91 | ALDH1A1 (0.74) | ALDH1A1ALOX15CTSLCTSKCTSB | |
| SCHEMBL329686 | 0.91 | ALDH1A1 (0.74) | ALDH1A1ALOX15CTSLCTSKCTSB | |
| Hydrochloric Acid SCHEMBL7928050 | 0.90 | ALDH1A1 (0.72) | ALDH1A1ALOX15CTSLCTSKCTSB | |
| SCHEMBL9301372 | 0.89 | ALDH1A1 (0.62) | ALDH1A1ALOX15CAPN1CTSLCTSK | |
| SCHEMBL9402445 | 0.89 | ALDH1A1 (0.62) | ALDH1A1ALOX15CAPN1CTSLCTSK | |
| SCHEMBL240653 | 0.89 | ALDH1A1 (0.62) | ALDH1A1ALOX15CAPN1CTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080545-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2011-12-20 | — | — | US | disclosed |
| US-20100144648-A1 | COMPOUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-7691852-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2010-04-06 | — | — | US | disclosed |
| US-20070293465-A1 | Compounds for enzyme inhibition | PROTEOLIX, INC. (US) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293465-A1 | Compounds for enzyme inhibition | PSME1, PSMB1, PSME3 | ALDH1A1 1307/4885ALOX15 1698/4885CAPN1 392/4885 |
| US-20100144648-A1 | COMPOUNDS FOR ENZYME INHIBITION | PSME1, PSMB1, PSME3 | ALDH1A1 1307/4885ALOX15 1698/4885CAPN1 392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.